Longevity Office operates as Germany’s first AI-supported longevity clinic and is physically based within the German Clinic for Diagnostics (DKD) in Wiesbaden. The medical team consists of experienced internists working within a structured clinical framework. It is a physician-led longevity clinic, combining preventive medicine and advanced diagnostics within a digital-first medical model.
The clinic applies a preventive and diagnostic-first approach, replacing isolated annual check-ups with a structured 12-month medical system. This system includes four major medical review stages, each informed by updated diagnostics and data analysis.
All consultations are conducted via secure video calls. Diagnostic tests can be completed at local laboratories across Germany, allowing patients to participate without regular on-site visits. The clinic operates independently, without sponsors or marketing partnerships, and limits its scope to peer-reviewed, evidence-based medical protocols.
Privacy and data security are treated as core clinical requirements. Medical information is handled within a physician-led workflow, with AI used solely as a support tool for data interpretation and continuity between appointments.
At a Glance – Longevity Office
- Location: Wiesbaden, Germany (DKD)
- Clinic Type: Physician-led longevity & preventive medicine clinic
- Core Focus: Early risk identification & healthspan planning
- Care Model: Digital-first, remote consultations
- Diagnostic Depth: Advanced blood panels, imaging, wearables
- Signature Method: 12-month structured system with four iterations
- Technology Use: Personalized Longevity-GPT (supportive, not decision-making)
- Privacy Level: Medical-grade confidentiality
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Many patients visiting Longevity Office Germany choose to arrive in Wiesbaden a day early or stay a little longer after their medical appointments. This extra time works like a soft landing. It allows the body and mind to slow down before returning to a busy work schedule. Wiesbaden is known for its calm, spa-inspired lifestyle and balanced pace. The city has wide green parks, quiet streets, and a long tradition of wellness and recovery. This peaceful environment naturally supports reflection, nervous system reset, and steady energy after focused longevity care.
For executives, founders, and high performers, this short buffer period is often a smart decision. Instead of switching overnight from structured medical sessions to meetings, flights, and deadlines, patients can rest and recalibrate. Think of it like cooling down after exercise. You recover better, think clearer, and protect long-term performance.
Wiesbaden also offers premium hotels and serviced apartments close to Longevity Office Germany. These accommodations provide comfort, privacy, and easy access to the clinic, while keeping the city’s relaxed rhythm within reach. Staying nearby helps patients extend the benefits of their longevity program beyond the consultation room.
Use the Quick Links below to navigate directly to the sections most relevant to your visit.
- Germany’s first AI-supported longevity practice: Medical expertise is combined with modern technology. Each patient receives a personalised, doctor-curated Longevity AI (Health-GPT) to support analysis, planning, and long-term decision-making.
- Structured 12-month medical system: Care follows a clearly defined model consisting of onboarding and three focused “Longevity Sprints,” replacing one-off annual check-ups with continuous medical optimisation.
- Location-independent digital care: The full program is designed to work remotely through video consultations and secure digital data uploads, removing the need for repeated clinic visits.
- Deep systems medicine framework: Health strategies target the five main risk domains—cardiovascular disease, cancer, metabolic health, performance decline, and biological ageing—using a triple approach: reduce harm, control progression, and strengthen protection.
- Data-driven transparency: Hundreds of lab markers, wearable sensor data, and imaging results are analysed together to build a clear, individual health roadmap that patients can understand and track over time.
Clinical Purpose
Longevity Office’s clinical purpose is to support the systematic extension of healthspan by identifying and managing disease risks at a pre-clinical stage. The clinic focuses on understanding how multiple biological systems interact over time, rather than responding to symptoms once disease is established.
Medical decisions are informed by comprehensive diagnostics, repeated data review, and physician oversight. The clinic’s role is to provide structure, interpretation, and continuity—without urgency framing, fear-based messaging, or outcome guarantees.
Who This Clinic Is Designed For
Based on its operational model and patient profiles, Longevity Office is designed for:
- Executives and senior professionals
- Founders and entrepreneurs
- Engineers, pilots, and technical specialists
- Investors and decision-makers
- Individuals with family histories of chronic illness
- Proactive adults seeking evidence-based prevention rather than reactive care
The clinic is not positioned for acute treatment or short-term wellness goals, but for individuals seeking clarity, oversight, and long-term medical planning.
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Focus Area
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What This Means in Practice
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Medical Discipline
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Preventive and systems-oriented medicine led by licensed physicians
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Core Biological System
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Cardiovascular risk, metabolic function, cancer risk, performance decline, biological aging
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Environment & Design
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Clinical, calm, privacy-focused setting with a digital-first care model
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Program Structure
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Structured 12-month medical system with continuous monitoring
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Lifestyle as Medicine
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Sleep, activity, glucose trends, and stress reviewed as medical data inputs
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Privacy
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Medical-grade data protection and discreet, physician-led information handling
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Long-Term Strategy
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Longitudinal monitoring and health planning rather than episodic care
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Longevity Office operates on a systems medicine philosophy. Rather than addressing isolated markers or symptoms, the clinic evaluates how multiple biological systems interact over time and how early risk patterns develop before disease becomes clinically visible.
The clinic deliberately positions itself away from reactive “sick-care.” Its framework focuses on pre-clinical risk identification, longitudinal observation, and physician-led interpretation of complex data. Medical decisions are grounded in peer-reviewed evidence and established clinical protocols, not trends, sponsored products, or wellness concepts.
According to Longevity Office founders Dr. Paul Weißenfels and Dr. Mario Domeyer, aging should be treated as a measurable biological process rather than a distant future concern, requiring structured monitoring long before symptoms appear.A defining principle is the avoidance of hype. Longevity Office does not promote experimental longevity claims or lifestyle promises. Instead, it applies structured medical reasoning to understand where risk is accumulating, how it evolves, and what requires monitoring over a defined period.
Core System Focus
Clinical attention is directed toward the primary drivers of age-related disease and mortality, referred to internally as “The 5 Attackers”:
- Cardiovascular risk
- Cancer risk
- Metabolic dysfunction
- Physical and cognitive performance decline
- Biological aging processes
Each area is assessed through validated diagnostics and reviewed across multiple iterations during the year.
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🔍 Did You Know?
According to large epigenetic studies published in Nature Aging and BMC Medicine, biological age can differ significantly from chronological age. Researchers show that lifestyle factors such as glucose control, sleep, and smoking avoidance influence the pace of aging far more than genetics alone.
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Lifestyle as a Medical Tool
Lifestyle factors—such as sleep, physical activity, and metabolic patterns—are evaluated as data inputs, not prescriptions. These elements are reviewed in relation to clinical markers to understand how daily behavior influences measurable risk.
Longevity Office applies high-resolution diagnostics to move beyond standard screening thresholds. The goal is not diagnosis of disease, but risk stratification and monitoring. A systematic review in Diabetes Care found that Continuous Glucose Monitoring (CGM) helps identify hidden metabolic stress that often remains invisible in standard fasting blood tests.
Additional research in the International Journal of Behavioral Nutrition and Physical Activity shows that real-time glucose feedback supports long-term behavior awareness rather than short-term dieting.
Diagnostic Assessment Includes
- Comprehensive blood biomarker panels
- Genetic and epigenetic testing
- Imaging studies (MRI / CT where clinically appropriate)
- Continuous Glucose Monitoring (CGM)
- Integration of wearable data (e.g., Apple Watch, Oura Ring)
Data is collected from specialty laboratories and local diagnostic centers across Germany, allowing patients to participate without centralized testing visits.
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🔍 Did You Know?
Long-term population studies published in BMC Medicine suggest that genetics account for less than 10% of how people age. More than 90% of aging outcomes are shaped by lifestyle, environment, and metabolic health.
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Chronomedicine & Future Risk Mapping
Diagnostics are repeated at structured intervals within a 12-month cycle, allowing physicians to observe changes over time. This longitudinal view supports future risk mapping by identifying trends, accelerations, or stabilizations across biological systems.
The emphasis remains on pattern recognition, not prediction certainty. Epigenetic research shows that changes in biological aging speed are best detected through repeated measurements over time, not single snapshots. Longitudinal tracking allows physicians to see whether risk markers are accelerating, stabilizing, or improving.
Key Medical Strength 1 – Continuous Medical Structure
Longevity Office replaces episodic appointments with a structured 12-month medical system consisting of four major review stages. Each iteration incorporates new diagnostic data and updated interpretation.
This structure allows physicians to assess whether risk markers are stable, improving, or progressing—something not possible with one-off check-ups.
Key Medical Strength 2 – Personalized Longevity-GPT Support
Each patient receives a custom Longevity-GPT, trained exclusively on their own medical data. The AI does not provide medical decisions or advice. Its role is to:
- Translate complex lab data into plain language
- Support patient understanding between appointments
- Help structure questions for physician consultations
This creates continuity between formal medical reviews without replacing physician authority.
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🔍 Did You Know?
According to research in Frontiers in Medicine, artificial intelligence is most effective in longevity medicine when used for data integration and pattern recognition — while final medical interpretation remains physician-led.
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Key Medical Strength 3 – Physician-Led Interpretation
Despite advanced data and AI support, clinical judgment remains central. All findings are reviewed by experienced physicians who contextualize results within the patient’s full medical and risk profile.
The clinic’s operating model is based on a Longevity Triangle:
- Physician (decision-making)
- AI (data organization and explanation)
- Patient (execution and awareness)
This structure supports informed participation without shifting responsibility away from medical professionals.
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🔍 Did You Know?
The widely cited “Hallmarks of Aging” framework, published in the International Journal of Molecular Sciences, explains that aging is driven by interconnected biological processes such as inflammation, metabolic dysfunction, and cellular stress — not by a single cause.
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The following outcomes are drawn directly from documented clinical case material and patient testimony referenced in the research. They are presented for contextual understanding only, not as expected or guaranteed results.
Outcome 1 – Metabolic Risk Identification
Before:
Elevated metabolic risk indicators, including markers associated with pre-diabetes, identified through advanced diagnostics.
After:
Significant weight reduction and normalization of metabolic markers following structured monitoring and medical oversight within the clinic’s 12-month system.
Source:
Clinical case documentation referenced in Longevity Office research materials.
Outcome 2 – Early Risk Visibility for High-Performers
Before:
No clear visibility into underlying cardiovascular and systemic risks through standard health checks.
After:
Identification of previously unrecognized risk factors within the first weeks of structured diagnostic review, enabling informed long-term planning.
Source:
Patient testimony (professional pilot) cited in clinic documentation.
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⚠️ Editorial Note
These outcomes reflect individual experiences reported within the clinic’s published materials. Results vary. Diagnostics indicate risk patterns, not certainty, and outcomes depend on multiple individual factors.
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Longevity Office structures its services around longitudinal medical oversight, not short-term interventions. Programs are designed to support continuous assessment, interpretation, and monitoring.
Program Overview
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Program
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Duration
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Overview
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12-Month Longevity Program
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12 months
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Structured medical system with four review stages, repeated diagnostics, and physician-led interpretation
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Personalized Longevity-GPT
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Ongoing
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AI trained on the patient’s medical data to explain results and support understanding between consultations
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Specialized Diagnostics
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As indicated
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Advanced testing including biomarkers, imaging, genetic and epigenetic analysis, CGM, and wearable data
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Remote Medical Oversight
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Ongoing
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Video consultations with diagnostics performed at local laboratories across Germany
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12-Month Longevity Program
This is the clinic’s core medical offering.
Program Characteristics:
- Structured 12-month medical cycle
- Four major diagnostic and review iterations
- Repeated reassessment of biomarkers and risk markers
- Physician-led interpretation at each stage
The program replaces isolated check-ups with a continuous medical system intended to support long-term health planning.
Personalized Longevity-GPT Integration
Each participant in the program receives access to a custom Longevity-GPT, trained exclusively on their individual medical data.
Role of the AI System:
- Explains diagnostic data in plain language
- Supports patient understanding between physician reviews
- Helps structure questions and observations for medical consultations
Note: The AI does not provide diagnoses, treatment decisions, or medical advice. All clinical interpretation remains physician-led.
Specialized Diagnostics & Monitoring
Programs may include access to advanced diagnostics referenced in the research, such as:
- Expanded blood biomarker panels
- Genetic and epigenetic testing
- Imaging studies where indicated
- Continuous glucose monitoring
- Integration of wearable data
These tools support detailed risk stratification and longitudinal observation within the clinic’s structured system.
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🔍 Did You Know?
Research published in the Journal of Medical Internet Research shows that wearable devices are most valuable when used for trend tracking over time, not as diagnostic tools on their own.
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Longevity Office operates within a clinical and diagnostic setting, not a therapeutic or wellness environment. The clinic is physically based at the German Clinic for Diagnostics (DKD) in Wiesbaden and functions primarily through a digital-first medical workflow.
Medical & Diagnostic Context
The clinic does not position its work around therapies or restorative treatments. Its activities are centered on:
- Diagnostic assessment
- Medical interpretation
- Longitudinal monitoring
All clinical actions are framed within preventive and systems medicine, with no spa, retreat, or lifestyle-treatment positioning.
Clinical Facilities
- Specialized diagnostic infrastructure
- Imaging capabilities
- Multidisciplinary medical expertise across multiple specialties
This setting supports the clinic’s focus on high-resolution diagnostics rather than on-site treatment delivery.
Environment, Privacy & Digital Discipline
Longevity Office emphasizes:
- Medical-grade data protection
- Secure digital communication
- Minimal operational friction for patients
The digital-first model allows patients to engage with the clinic without repeated physical presence, while maintaining structured medical oversight.
Longevity Office does not publicly list fixed package prices. According to the research, pricing follows the German Medical Fee Schedule (GOÄ) and is determined based on diagnostic scope and medical services provided.
Pricing
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Category
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Details
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Clinic Positioning
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Private, physician-led medical practice
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Pricing Basis
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GOÄ (German Medical Fee Schedule)
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Public Price List
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Not published
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Cost Drivers
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Diagnostics, physician time, program duration
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Commercial Framing
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Medical service-based, not packaged wellness
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Program Structure
The clinic’s core structure is a 12-month system, characterized by:
- Four structured medical review iterations
- Repeated diagnostic reassessment
- Ongoing data integration and interpretation
This structure is designed to support continuity and trend analysis, rather than short-term engagement.
Length of Stay
There is no required on-site stay. All medical consultations are conducted via video, and diagnostic testing can be completed at local laboratories throughout Germany. Physical presence in Wiesbaden is not a prerequisite for participation.
Longevity Office is designed as a digital-first medical clinic. Participation does not require a fixed on-site stay. Most patients engage remotely, with diagnostics completed locally and consultations conducted via video.
Recommended Length of Stay
- No mandatory on-site stay
- Medical consultations are conducted remotely
- Diagnostic testing can be completed at local laboratories across German
- Physical presence in Wiesbaden is optional and context-dependent
The clinic’s model prioritizes continuity and longitudinal assessment rather than intensive short-term visits.
How to Reach Wiesbaden?
For individuals who choose or need to visit Wiesbaden:
- Nearest major airport: Frankfurt am Main Airport
- Approximate transfer time: ~30 minutes to Wiesbaden
- Transport options: Train or car
Travel planning is outside the clinic’s core medical services and is managed independently by patients.
🔗 Find best flights to Wiesbaden
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Links provided for travel planning convenience only.
Accommodation & Stay Planning
Longevity Office does not operate its own accommodation. Patients who choose to visit Wiesbaden typically stay in nearby hotels or private accommodation, selected independently based on personal preference, schedule, and comfort requirements. For convenience, the Stay22 map below allows visitors to explore accommodation options around the clinic’s location, compare areas, and plan a stay that fits their itinerary.
🔗 Explore nearby hotels & apartments
What to Bring
- Relevant prior medical records (if available)
- Access to wearable data, if already in use
What Patients Commonly Report
Based on documented patient testimonials and clinical case material included in the research, patients commonly report:
- Greater clarity around complex medical data and biomarkers
- Improved understanding of personal risk factors before symptoms appear
- A sense of continuity between formal medical consultations
- Increased confidence in long-term health planning decisions
Several patients highlight the value of having ongoing access to structured explanations of their data, particularly between physician reviews, rather than receiving isolated reports once per year.
Professional & Peer Recognition
Longevity Office is positioned within Germany’s preventive and systems medicine landscape and operates from the German Clinic for Diagnostics (DKD) in Wiesbaden. Its work is referenced through:
- The clinic’s own Evidence Hub and published clinical protocols
- Physician-authored explanations of its medical framework
- Patient testimonials from medical professionals, engineers, executives, and scientists
Expert voices associated with the clinic, including its founding physicians, emphasize a shift away from reactive care toward structured, data-driven prevention. This positioning is professional rather than media-driven, with no reliance on lifestyle press or wellness endorsements.
What is the Longevity Office in Germany?
Longevity Office is a physician-led longevity and preventive medicine clinic based in Wiesbaden, Germany. It focuses on advanced diagnostics, early risk identification, and long-term medical monitoring through a structured 12-month system.
Where is the Longevity Office located?
Longevity Office is physically located in Wiesbaden, Germany, within the German Clinic for Diagnostics (DKD). Most medical services are delivered through a digital-first model.
Is the Longevity Office a medical clinic or a wellness center?
Longevity Office operates as a medical clinic, not a wellness or spa center. Its work is diagnostic and preventive, led by licensed physicians and based on evidence-driven medical protocols.
How does the Longevity Office differ from a standard health check-up?
Unlike a one-time annual check-up, Longevity Office uses a 12-month structured medical system with four review stages. This allows physicians to observe trends and changes in health markers over time.
Does the Longevity Office provide treatment or therapy?
No. Longevity Office focuses on risk identification, monitoring, and medical interpretation. It does not provide treatment, guarantee outcomes, or replace a personal physician.
What is Longevity-GPT at the Longevity Office?
Longevity-GPT is a personalized AI system trained on a patient’s own medical data. It helps explain diagnostics in plain language and supports continuity between physician consultations, without making medical decisions.
Who is the Longevity Office designed for?
The clinic is designed for executives, founders, investors, engineers, pilots, and other high-performers seeking clarity and long-term medical planning rather than short-term interventions.
Do patients need to travel to Wiesbaden?
No. Longevity Office operates primarily through remote consultations, and diagnostic tests can be completed at local laboratories across Germany. Travel to Wiesbaden is optional.
How long do Longevity Office programs last?
The clinic’s core program operates over 12 months, with four structured diagnostic and review iterations.
Is the Longevity Office suitable for people with chronic conditions?
The clinic does not treat chronic conditions. It may support risk monitoring and structured assessment, while all treatment decisions remain with the patient’s personal physician.
Is pricing publicly available for the Longevity Office?
No. Pricing is not publicly listed and is described as being based on the German Medical Fee Schedule (GOÄ), depending on diagnostic scope and medical services.
Is the Longevity Office focused on anti-aging?
No. Longevity Office does not claim anti-aging outcomes. Its focus is on healthspan planning, risk awareness, and evidence-based longevity medicine.
How is patient data handled at the Longevity Office?
Patient data is managed within a medical-grade privacy framework, with physician-led oversight and secure digital systems.
Longevity Office is structured for individuals who approach health decisions with the same discipline they apply to business, engineering, or investment strategy. The clinic does not frame longevity as a promise or an outcome. Instead, it offers a methodical, physician-led framework for understanding health risks over time.
By combining advanced diagnostics, repeated assessment, and clinical interpretation within a structured system, Longevity Office supports informed decision-making without urgency or speculation. Its value lies in clarity over complexity, continuity over isolated check-ups, and evidence over assumption.
For executives, founders, investors, and high-performers, the clinic functions as a medical insight partner—providing structured visibility into health markers that are often overlooked until symptoms appear, while leaving all treatment decisions with the individual and their personal physician.
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Disclaimer
This page is published for informational and editorial purposes only as part of the ExtendMy.Life clinic profiling framework. It is intended to support general understanding, comparative context, and informed decision-making and should not be interpreted as medical guidance, diagnosis, or treatment advice. No content on this page establishes or implies a doctor–patient relationship between the reader and Longevity Office, its physicians, or any associated medical professionals. All descriptions of diagnostics, programs, technologies, and medical frameworks are presented at a high-level, non-instructional overview. Any references to diagnostics, biomarkers, monitoring systems, or longevity frameworks are provided to describe clinical scope and methodology, not to predict outcomes or suggest medical action. Diagnostic findings indicate risk patterns and probabilities, not certainty, and may vary significantly between individuals. Longevity Office does not claim to cure, treat, reverse, or prevent disease, nor does it guarantee health outcomes, performance improvements, or lifespan extension. All medical decisions, interpretations, and actions must be made solely by the reader in consultation with their personal, qualified healthcare provider. ExtendMy.Life does not provide medical services, does not endorse specific medical interventions, and does not act as a substitute for professional medical advice.. Readers are encouraged to conduct independent evaluation and to seek appropriate professional counsel before making any health-related decisions.
References
Belsky, D.W., Caspi, A., Arseneault, L., et al. (2025) ‘Lifestyle factors and epigenetic aging: longitudinal cohort analysis’, BMC Medicine, 23(1), pp. 1–14. Available at: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04394-3 (Accessed: 14 January 2026).
Horvath, S., Raj, K., Chen, B.H., et al. (2025) ‘DNA methylation age and mortality risk: systematic review and meta-analysis’, Nature Aging. Available at: https://pubmed.ncbi.nlm.nih.gov/40429598/ (Accessed: 14 January 2026).
López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M. and Kroemer, G. (2025) ‘Hallmarks of aging: implications for longevity interventions’, International Journal of Molecular Sciences, 25(12), 6793.
Available at: https://www.mdpi.com/1422-0067/25/12/6793 (Accessed: 14 January 2026).
Huang, Y., Hu, J., Chen, L., et al. (2025) ‘Continuous glucose monitoring in adults: systematic review and meta-analysis’, Diabetes Care. Available at: https://pubmed.ncbi.nlm.nih.gov/39716288/ (Accessed: 14 January 2026).
Aminian, S., Hinckson, E., Stewart, T. and Duncan, S. (2024) ‘Continuous glucose monitoring as a catalyst for lifestyle modification in adults’, International Journal of Behavioral Nutrition and Physical Activity, 21, 16. Available at: https://link.springer.com/article/10.1186/s12966-024-01622-6 (Accessed: 14 January 2026).
Piwek, L., Ellis, D.A., Andrews, S. and Joinson, A. (2025) ‘Wearable technology in health monitoring: systematic review’, Journal of Medical Internet Research. Available at: https://pubmed.ncbi.nlm.nih.gov/37671030/ (Accessed: 14 January 2026).
Ahmad, T., Zhang, J., Khan, M., et al. (2025) ‘AI and multi-omic integration for precision longevity medicine’, Frontiers in Medicine. Available at: https://pubmed.ncbi.nlm.nih.gov/39418098/ (Accessed: 14 January 2026).
Thor, D., Barzilai, N., Lyu, Y.X. and Spiru, L. (2026) ‘From sick care to healthspan: educating the longevity physician for health maintenance and health promotion’, Biogerontology, 27(22). Available at: https://link.springer.com/article/10.1007/s10522-025-10371-3 (Accessed: 14 January 2026).
World Health Organization (WHO) (2023) Decade of Healthy Ageing: Baseline Report. Geneva: World Health Organization. Available at: https://www.who.int/initiatives/decade-of-healthy-ageing (Accessed: 14 January 2026).
International Institute of Longevity (IIOL) and Buck Institute for Research on Aging (2023) In Search of Best Practices for Longevity Clinics: IIOL White Paper 2023. Available at: https://iiol.eu/wp-content/uploads/2024/12/IIOL-whitepaper_2023.pdf (Accessed: 14 January 2026).
